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For more than a decade, we have compared responses of mesic (subhumid) savanna grasslands (>500 mm MAP in the tropics and >600 mm MAP outside the tropics) in North America and South Africa to alterations in both fire and grazing regimes. The long-term, comparative experiment that forms the centerpiece of this cross-continental research program is located in tallgrass prairie at the Konza Prairie Biological Station (Kansas, USA) and in knob-thorn marula savanna at the Kruger National Park (Limpopo and Mpumalanga provinces, South Africa).